Efficacy of Tacrolimus 0.03% Ointment in Resistant Meibomian Gland Dysfunction

Authors

  • Bilal Khan Khyber Medical College, Khyber Teaching Hospital, Peshawar
  • Adnan Ahmad Nowshera Medical College, Qazi Hussain Ahmad Medical Complex, Nowshera
  • Javed Rasul Pak International Medical College, Peshawar Institute of Medical Sciences, Peshawar
  • Muhammad Farhan Nowshera Medical College, Qazi Hussain Ahmad Medical Complex, Nowshera
  • Hamid Rehman Bannu Medical College, Khalifa Gul Nawaz Hospital, Bannu

Keywords:

Meibomian Gland Dysfunction, Ointment, Tacrolimus

Abstract

Aim: To determine the efficacy of 0.03% Tacrolimus ointment in treating resistant meibomian gland dysfunction.

Study design: Interventional case series.

Duration and Settings of the Study: From January 2021 to June 2021 at the Department of Ophthalmology, Khyber Teaching Hospital Peshawar.

Methods: Patients with meibomian gland dysfunction resistant to conventional therapy were included in the study. All of them were treated with Tacrolimus 0.03% dermatological ointment applied twice daily to eyelashes and lid margins along with lid hygiene measures. The patients were evaluated for any improvement in the subjective and objective features of the disease with therapy by conducting assessments at 2nd and 4th week of therapy and were then compared with the baseline features.

Results: A total of 18 participants (36 eyes) with mean age and + standard deviation of 40 + 12.4 year participated in the study. There was no statistically significant improvement in certain parameters like inferior tear meniscus level (p=0.09), meibum quality (p=0.88), conjunctival redness (p=0.18), and telangiectasia of the lower eyelid (p=0.9). However, the fluorescein staining score (p=0.03) and telangiectasia of the upper eyelid (p=0.02) showed statistically significant improvements. As far as the subjective features of the disease were concerned, significant improvement in ocular itching (p=0.04) and dryness (p=0.03) was observed.

Conclusion: Topical application of Tacrolimus 0.03% ointment showed improvement in the fluorescein staining score, telangiectasia of the upper eyelid, ocular itching and dryness in meibomian gland dysfunction in resistant cases.

Author Biographies

Bilal Khan, Khyber Medical College, Khyber Teaching Hospital, Peshawar

Assistant Professor: Department of Ophthalmology

Adnan Ahmad, Nowshera Medical College, Qazi Hussain Ahmad Medical Complex, Nowshera

Associate Professor: Department of Ophthalmology

Javed Rasul, Pak International Medical College, Peshawar Institute of Medical Sciences, Peshawar

Assistant Professor: Department of Ophthalmology

Muhammad Farhan, Nowshera Medical College, Qazi Hussain Ahmad Medical Complex, Nowshera

Assistant Professor: Department of Ophthalmology

Hamid Rehman, Bannu Medical College, Khalifa Gul Nawaz Hospital, Bannu

Assistant Professor: Department of Ophthalmology

Downloads

Published

05-01-2024

How to Cite

Bilal Khan, Adnan Ahmad, Javed Rasul, Muhammad Farhan, & Hamid Rehman. (2024). Efficacy of Tacrolimus 0.03% Ointment in Resistant Meibomian Gland Dysfunction. Journal of Clinical and Community Ophthalmology, 2(01), 2–6. Retrieved from https://jcco.pico.org.pk/index.php/jcco/article/view/53

Issue

Section

Original Article

Most read articles by the same author(s)